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KMID : 0363320080290041025
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Journal of Korean Oriental Internal Medicine
2008 Volume.29 No. 4 p.1025 ~ p.1036
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The Effects of Gypsum on Streptozotocin-induced Diabetic Nephropathic Rats
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Hong Gwang-Hae
Lee Kwun-Ho
Jeong Gi-Hoon
Kim Yong-Sung
Lee Hyun-Ju
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Abstract
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Objectives: The aim of present study was to investigate recovery effects of gypsum, which has been used clinically in diabetes therapy.
Methods: We established three groups, normal, control, and gypsum, and assigned 6 rats to each group. The normal group was not treated by any process and fed normal saline. The control & gypsum groups were administered streptozotocin(STZ) to induce diabetes. Gypsum extract was orally administered to the gypsum group for 10 days. After 8 weeks, the rats were sacrificed and their body weight, 24hrs urinary protein excretion, glucose, albumin, BUN, creatinine, total-cholesterol, LDL-cholesterol, triglyceride in blood, level of glycation end-product (AGE) and transforming growth factor (TGF-β1) in serum were measured. Morphological profiles and morphometric studies of the kidney cortex. renal transforming growth factor (TGF-β1) expression, macrophage/monocyte antigen (ED-1), and type IV collagen expression were studied.
Results: The following results were obtained. The protein amount in urine per 24hrs of the gypsum-treated group as compared to the control was significantly reduced. The BUN and creatinine level in serum of the gypsum-treated group as compared to the control was significantly inhibited. The construction change in the kidneys of the gypsum-treated group as compared to the control was significantly inhibited. The factor of the gypsum-treated group as compared to the control was significantly inhibited. which induced the structural change in the kidneys.
Conclusions: The above results suggest that gypsum partially improved kidney function.
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KEYWORD
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Gypsum, Streptozotocin, Diabetic Nephropathic Rats
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